Bird-Flu Resistance to Tamiflu Vaccine?

From the AP, not good news:

In a development health experts are calling alarming, two bird flu patients in Vietnam died after developing resistance to Tamiflu, the key drug that governments are stockpiling in case of a large-scale outbreak.

The experts said the deaths were disturbing because the two girls had received early and aggressive treatment with Tamiflu and had gotten the recommended doses.

The new report suggests that the doses doctors now consider ideal may be too little. Previous reports of resistance involved people who had taken the drug in low doses; inadequate doses of medicine are known to promote resistance by allowing viruses or bacteria to mutate and make a resurgence.

Dr. Anne Moscona, a flu expert at Weill Cornell Medical College in New York City, called the deaths frightening and said they demonstrate the dangers of hoarding drugs.
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Concerns about Tamiflu resistance surfaced in October when doctors discovered it in a 14-year-old Vietnamese girl who had been given low doses as a precaution because she was caring for a brother with bird flu. She survived, and doctors theorized the low doses caused the resistance.
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Roche [Tamiflu's manufacturer] is conducting animal studies of different dosages to see which works best. Results are expected early next year.